RehmaAI synthesizes evidence across biomedical literature, clinical trial registries, and genomics databases — returning structured, source-traced hypotheses with a human gate at every step.
RehmaAI is scoped to cancer biology. It retrieves, cross-references, and synthesizes evidence across specialized oncology sources — not the open web.
PubMed oncology journals and cancer biology publications. Queries return structured summaries with citation trails — not ranked document lists.
ClinicalTrials.gov and oncology-specific registries. Surfaces active, completed, and terminated trials relevant to a research question with endpoint data.
TCGA, COSMIC, and curated cancer genomics databases. Biomarker and mutation data linked to relevant clinical and translational evidence.
Structured evidence packages with supporting findings, counterevidence, and uncertainty flags. Every dossier requires researcher review and approval before any experimental step.
Longitudinal tracking of research questions, findings, and outcomes — including negatives. Institutional knowledge accumulates across research cycles.
The model does not retrain on clinical data automatically. Learning is deliberate: reviewed, approved, and versioned. Every AI decision is permanently logged.
Oncology research produces evidence faster than any team can systematically review. PubMed indexes more than 800,000 biomedical articles annually. ClinicalTrials.gov lists over 460,000 registered studies. TCGA and COSMIC together hold genomic profiles across dozens of cancer types.
The bottleneck is not data volume — it is structured synthesis across sources. A signal in COSMIC may already have an active trial in ClinicalTrials.gov and three contradicting papers in PubMed. Finding that constellation manually takes weeks. Missing it means duplicated effort, or a hypothesis that was quietly disproved years ago.
RehmaAI is built to close that gap: a structured, traceable path from a research question to a dossier a researcher can evaluate and act on.
"The challenge is not generating hypotheses. It is knowing which ones are supported, which are contradicted, and which have already been tested."
Intelligence without governance is liability. No step in the pipeline advances without a deliberate human action.
A researcher submits a cancer research question or hypothesis candidate through the workspace. The system structures it into a retrievable query.
The RAG engine queries PubMed, ClinicalTrials.gov, TCGA, and COSMIC in parallel, pulling primary source records against the structured query.
Retrieved records are synthesized into a structured dossier: supporting evidence, counterevidence, uncertainty flags, and a full citation trail.
The dossier reaches the researcher's queue. No hypothesis advances to any experimental consideration without an explicit researcher decision.
Every outcome — confirmed, refuted, or inconclusive — is recorded with the full dossier. Negative findings are logged with the same rigor as positive ones.
Validated signals accumulate as citable discovery outputs. The registry compounds over research cycles, reducing redundant effort across teams.
RehmaAI queries curated sources in cancer biology and translational oncology — not the open web. Each source is indexed, versioned, and attribution-tracked.
Oncology-filtered journal articles, preprints via Europe PMC, and cancer biology publications with citation-level retrieval.
Active, completed, and terminated oncology trials with endpoint data, eligibility criteria, and sponsor information.
The Cancer Genome Atlas and Catalogue of Somatic Mutations in Cancer — mutation frequency, gene expression, and biomarker data across cancer types.
GEO, cBioPortal, and curated oncology trial registries are in scope for subsequent data-access agreements. All sources require institutional review before activation.
RehmaAI's initial validation study is built around a 124-patient retrospective cohort of Stage IV Non-Small Cell Lung Cancer, covering first-line systemic therapy episodes. Primary endpoints are overall survival and time to next treatment. EGFR, ALK, PD-L1, and KRAS biomarker status are included for each patient in scope.
Data feasibility review is being finalized with an oncology center. Pilot launch is scheduled for Q1 2027. The study design is available for academic review on request.
Request study briefThese are constraints, not aspirations. They are encoded into the system architecture.
RehmaAI is a research tool. It surfaces evidence for researcher evaluation. It does not generate, rank, or suggest treatment pathways for individual patients.
The AI model does not update from clinical data automatically. Retraining is a deliberate decision — reviewed, approved, and version-logged by the research team.
Every dossier requires an explicit researcher decision before any experimental consideration. The system cannot escalate a signal to an action.
Every statement in a dossier links to its primary source. Synthetic summaries that cannot be traced to a source document are flagged as uncertain, not presented as findings.
RehmaAI does not produce validated drug candidates. Discovery outputs are research signals that require experimental confirmation through standard scientific process.
A multidisciplinary team combining oncology expertise, AI research, and health systems experience.
RehmaAI is in active development with a limited number of academic oncology research partners. If you are building a research program in oncology or cancer biology and want to explore a collaboration, we would like to hear from you.
We are particularly interested in partnerships around retrospective cohort data access, endpoint validation methodology, and translational oncology research design.
We have received your request and will be in touch within 2 business days.